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酸枣仁(Ziziphus Jujuba Mill seeds)总皂甙(简称ZS)静脉注射可明显降低麻醉大鼠和猫的血压:腹腔注射对麻醉大鼠亦有明显降压作用。阿托品和苯海拉明不影响其降压效应;对去甲肾上腺素的升压作用亦无影响。ZS能明显地抑制中枢加压反射和内脏大神经节前纤维的自发性放电,表明ZS的降压作用可能是通过中枢神经系统实现的.ZS还能降低血浆肾素活性。
Ziziphus Jujuba Mill seeds total saponins (ZS for short) can significantly reduce the blood pressure of anesthetized rats and cats: intraperitoneal injection also has significant antihypertensive effect on anesthetized rats. Atropine and diphenhydramine did not affect its antihypertensive effect; nor did it affect the boosting effect of norepinephrine. ZS can significantly inhibit the central pressure reflex and spontaneous discharge of splanchnic major ganglion fibers, indicating that the antihypertensive effect of ZS may be achieved through the central nervous system. ZS can also reduce plasma renin activity.