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通过调变镁铁尖晶石的含量,采用一步共沉淀法制备了一系列具有核壳结构的水滑石型磁性纳米载药粒子,对其微结构、热稳定性、磁性和药物释放性能进行了系统的研究.结果表明这种磁性纳米载药粒子是一种具有以镁铁尖晶石为核层、双氯酚酸(Diclofenac,DIC)插层水滑石(DIC-LDH)为壳层的复合纳米粒子,粒径在90～180 nm之间.其中壳层DIC-LDH的晶粒尺寸D110和层板电荷密度随磁核含量的增大而逐渐减小.磁性纳米载药粒子的载药量随磁核含量的增大而逐渐减小,而其比饱和磁化强度则随着磁核含量的增大逐渐增大.体外释放实验表明,无外加磁场时,磁核含量增大,壳层DIC-LDH粒径减小,磁性纳米载药粒子药物释放速率逐渐增大;外加1500 G磁场时,磁核含量增大,磁致团聚程度增大,其药物释放速率逐渐减小.
A series of hydrotalcite-based magnetic nanoparticles with core-shell structure were prepared by one-step coprecipitation method by adjusting the content of spinel. The microstructure, thermal stability, magnetism and drug release properties were investigated System.The results show that the magnetic nano-drug-loaded particle is a composite with DIC-LDH as shell layer with magnesia-iron spinel as the core layer and Diclofenac (DIC) Nanoparticles with a diameter of 90 ~ 180 nm, in which the crystal size of the DIC-LDH and the charge density of the layer gradually decrease with the increase of the magnetic core content. With the increase of magnetic core content decreases, and its specific saturation magnetization increases with the increase of magnetic core content in vitro release experiments show that without magnetic field, the magnetic core content increases, the shell DIC -LDH particle size decreases, the drug release rate of magnetic nano-drug-loaded particles increases gradually; when the magnetic field of 1500 G is applied, the magnetic core content increases and the degree of magnetic agglomeration increases, and the drug release rate decreases gradually.