临床在使用某些药物时,有时不但达不到应有的药效,反而起到相反的作用,常使病人或医生误认为是用药量不足,或认为是病情加重,而加大用药剂量,这样势必造成严重后果。根据近年来文献报道,有下列几种情况,应引起人们重视: 一、抗心绞痛药引起心绞痛发作 国外学者发现,少部分冠心病病人舌下含服硝酸甘油片治疗心绞痛,反使心绞痛加重,并见心电图发生新的缺血性改变。这是因为该药可以使周围血管扩张,导致静脉瘀血,造成相对性冠脉缺血加重所致。用心痛定、尼群地平等钙拮抗剂较大剂量时,因 In the clinical use of certain drugs, sometimes not only fail to meet the desired efficacy, but on the contrary, the patient or doctor often mistaken for the lack of medication, or that the disease is aggravated, and increase the dosage, This will inevitably lead to serious consequences. According to reports in recent years, there are several cases that should be paid attention to: First, angina pectoris caused by angina pectoris Foreign scholars found that a small portion of patients with coronary heart disease sublingual nitroglycerin tablets for the treatment of angina, angina pectoris, and See ECG new ischemic changes. This is because the drug can cause peripheral blood vessels to dilate, causing venous stasis, resulting in increased relative coronary ischemia. Heartache, nitrendipine equivalent calcium antagonist at higher doses, due to