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由于心肌细胞的增殖能力很低 ,细胞移植作为一种新的治疗方法用于改善心功能及心肌活力已受到广泛的关注。目前已有胚胎干细胞、骨髓间充质干细胞和内皮干细胞在体外诱导分化为心肌细胞 ;动物实验中用于心肌移植的细胞有胚胎心肌细胞、造血干细胞、骨髓间充质干细胞、骨骼肌成肌细胞、内皮干细胞、肝干细胞和神经干细胞。其中成肌细胞移植用来改善心肌梗死后的心脏功能 ,已有临床报道 ,并取得成功
Due to the low proliferation capacity of cardiomyocytes, cell transplantation as a new treatment method for improving cardiac function and myocardial viability has received widespread attention. At present, embryonic stem cells, bone marrow mesenchymal stem cells and endothelial stem cells have been induced to differentiate into cardiomyocytes in vitro. The cells used for cardiac transplantation in animal experiments include embryonic cardiomyocytes, hematopoietic stem cells, bone marrow mesenchymal stem cells, skeletal myoblasts , Endothelial stem cells, liver stem cells and neural stem cells. Among them, myoblast transplantation used to improve cardiac function after myocardial infarction has been reported clinically and achieved success