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目的 :对比研究格列吡嗪控释片与格列吡嗪速释片对Ⅱ型糖尿病的疗效。方法 :选择 80例Ⅱ型糖尿病患者 ,给予格列吡嗪控释片 (n =5 0 )和格列吡嗪速释片 (n =3 0 )治疗 ,观察两组治疗前后血糖和胰岛素的变化。结果 :格列吡嗪控释片每日一次服用的降糖效果与格列吡嗪速释片每日 2～ 3次服用效果相同 ;后者治疗后空腹和餐后胰岛素较前者明显升高。结论 :格列吡嗪控释片有较好的降糖效果 ,同时不引起高胰岛素血症
Objective: To compare the curative effect of glipizide controlled-release tablets and glipizide immediate-release tablets on type 2 diabetes mellitus. Methods: Eighty patients with type Ⅱ diabetes mellitus were treated with glipizide (n = 50) and glipizide (n = 30). The changes of blood glucose and insulin before and after treatment were observed . Results: Glipizide controlled-release tablets take daily hypoglycemic effect and glibenclamide fast release tablets taken 2 to 3 times a day the same effect; the latter fasting and postprandial insulin was significantly higher than the former. Conclusion: Glipizide controlled-release tablets have better hypoglycemic effect, while not causing hyperinsulinemia