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目的研究cyclinD1、P53蛋白在胰腺癌中的表达,阐明其与胰腺癌的相关性。方法采集临床胰腺癌患者标本,采用免疫组化SP法检测cyclinD1、P53蛋白表达水平,检测其与临床各项指标的关系。结果胰腺癌中cyclinD1的阳性表达率是70.85%,P53在胰腺癌中的阳性表达率为56.60%。结论cyclinD1可以作为早期诊断胰腺癌的生物学指标。而p53在胰腺癌的发生、发展过程中起重要的协同作用。
Objective To study the expression of cyclinD1 and P53 protein in pancreatic cancer and elucidate the correlation between them and pancreatic cancer. Methods The specimens of patients with pancreatic cancer were collected. The expression of cyclinD1 and P53 protein was detected by immunohistochemical SP method and the relationship between them and clinical indexes was examined. Results The positive rate of cyclinD1 in pancreatic cancer was 70.85%, and the positive rate of P53 in pancreatic cancer was 56.60%. Conclusion cyclinD1 can be used as a biological indicator for early diagnosis of pancreatic cancer. However, p53 plays an important synergistic role in the development and progression of pancreatic cancer.