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对不同甲状腺疾病患者和正常人应用酶联免疫吸附试验（ＥＬＩＳＡ）、免疫印迹法（Ｗｅｓｔｅｒｎ－ｂｌｏｔ）及四甲基偶氮唑盐（ＭＴＴ）比色分析法分别检测抗０：３、０：９血清型小肠结肠炎耶尔森菌（Ｙｅｒｓｉｎｉａｅｎｔｅｒｏｃｏｌｉｔｉｃａ，下简称耶氏菌）抗体、耶氏菌质粒释放蛋白（ＲＰｓ）抗体及外周血淋巴细胞对ＲＰｓ特异性转化反应。结果：Ｇｒａｖｅｓ病（ＧＤ）患者抗０：３血清型耶氏菌抗体及ＲＰｓ－Ａｂ阳性率均明显高于正常对照组（Ｐ＜０．０１）；ＧＤ患者淋巴细胞刺激指数明显高于对照组（Ｐ＜０．０５）。认为耶氏菌感染可能为ＧＤ发病病因之一。
Anti-0: 3, 0: 3 were detected by enzyme-linked immunosorbent assay (ELISA), Western-blot and MTT colorimetric assay in patients with different thyroid diseases and normal controls. 9 antibody against Yersinia enterocolitica, antibodies against Yersinia pestis and RPE and peripheral blood lymphocytes to RPs. Results: The positive rates of anti-0: 3 serotypes of Yersinia pestis and RPs-Ab in patients with Graves disease (GD) were significantly higher than those in normal controls (P <0.01). The lymphocyte stimulation index in GD patients was significantly higher than that in controls (P <0.05). Yersinia infection that may be one of the causes of GD.