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目的探讨单唾液酸四己糖神经节苷脂(GM1)治疗急性脑出血的疗效。方法将76例急性脑出血患者分为治疗组与对照组,观察并比较GM1及常规治疗对2组患者的美国国立卫生研究院卒中量表(NIHSS)和改良Rankin评分(mRS)的影响。结果与基线水平相比,2组患者治疗后1月的NIHSS评分和治疗后3月的MRS评分差异均有统计学意义(P<0.05或P<0.01)。治疗组的NIHSS及mRS评分改善程度优于对照组(P均<0.01)。结论 GM1对急性脑出血治疗可能有效。
Objective To investigate the efficacy of monosialotetrahexosyl gangliosides (GM1) in the treatment of acute cerebral hemorrhage. Methods A total of 76 patients with acute cerebral hemorrhage were divided into treatment group and control group. The effects of GM1 and routine treatment on NIH Stroke Scale (NIHSS) and modified Rankin score (mRS) were compared between the two groups. Results The NIHSS scores at 1 month after treatment and the MRS scores at 3 months after treatment in both groups were significantly lower than those at baseline (P <0.05 or P <0.01). The NIHSS and mRS scores of the treatment group were better than those of the control group (all P <0.01). Conclusion GM1 may be effective in the treatment of acute cerebral hemorrhage.