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目的：既往的研究表明幽门括约肌的收缩与舒张受胆碱能神经、肾上腺素能神经、多肽能神经和NOS神经的调节。本研究探讨幽门松弛与胆汁返流的关系及肠血管活性肽（VIP）和一氧化氮（NO）对幽门松弛的影响。方法：通过胃镜检查把幽门功能分为3组：幽门松弛组、幽门运动组、幽门闭合组。测定胃液中的甘胆酸和pH值及作胃窦粘膜病理检查，了解3组患者的十二指肠胃返流情况，并取幽门局部粘膜，测定其VIP和NO含量。结果：幽门松弛组十二指肠胃返流率为55.6%，明显高于幽门运动组和幽门闭合组。幽门松弛组局部粘膜NO的含量明显高于其它组，而3组间VIP的含量无显著差别。结论：幽门松弛是胆汁返流的主要原因，局部NO增高是幽门松弛的重要原因。
PURPOSE: Previous studies have shown that the contraction and relaxation of pyloric sphincter are regulated by cholinergic, adrenergic, polypeptide and NOS nerves. This study was aimed to investigate the relationship between pyloric relaxation and bile reflux and the effect of intestinal vasoactive peptide (VIP) and nitric oxide (NO) on pyloric relaxation. Methods: Pylorus function was divided into 3 groups by gastroscopy: pyloric relaxation group, pyloric exercise group, pyloric closure group. The gastric juice in the determination of glycocholic acid and pH value and gastric mucosa for pathological examination to understand the three groups of patients with duodenal reflux, and take the pylorus mucosa, determination of VIP and NO content. Results: The rate of duodenal reflux was 55.6% in pyloric relaxation group, which was significantly higher than that in pylorus motor group and pyloric closure group. The contents of NO in the mucosa in pyloric relaxation group were significantly higher than those in the other groups, while there was no significant difference in VIP content among the three groups. Conclusion: Pyloric relaxation is the main reason of bile reflux. Elevated NO is an important cause of pyloric relaxation.