本文研究了海藻酸钙微球的包裹药物效率、微球的粒度分布,表面结构及结块程度。含5%海藻酸钠水溶液100g:羟丙基甲基纤维素(9:1)及不同浓度的茶碱分散于异辛烷150g(内含2％司盘85),用机械搅拌1000rpm10分钟,加入含2g吐温85的水溶液10g,再搅拌5分钟,然后加入50g8％氯化钙溶液,与分散的聚合物小球反应10分 In this paper, the drug loading efficiency of calcium alginate microspheres, particle size distribution, surface structure and agglomeration of microspheres were investigated. 100 g of 5% sodium alginate aqueous solution: hydroxypropyl methylcellulose (9: 1) and theophylline of different concentrations were dispersed in 150 g of isooctane (containing 2% Span 85), mechanically stirred at 1000 rpm for 10 minutes, Containing 2g Tween 85 aqueous solution of 10g, and then stirred for 5 minutes, then add 50g of 8% calcium chloride solution, and dispersed polymer beads reaction 10 minutes