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目的:探讨核转录因子κBp65(NF-κBp65)在喉癌中的表达及临床意义。方法:采用免疫组织化学及原位杂交方法,检测48例喉癌组织和20例正常喉黏膜组织中NF-κBp65的表达水平及与肿瘤生物学行为间的关系。结果:①NF-κBp65的表达在喉癌与正常喉黏膜组织间的差异有统计学意义(P<0.05)。②NF-κBp65的高表达与颈淋巴结转移和临床分期有相关性,而与肿瘤部位及病理分化无相关性。结论:NF-κBp65是判断喉癌预后极具价值的指标。
Objective: To investigate the expression of nuclear factor κBp65 (NF-κBp65) in laryngeal carcinoma and its clinical significance. Methods: The expression of NF-κBp65 in 48 cases of laryngeal carcinoma and 20 cases of normal laryngeal mucosa was examined by immunohistochemistry and in situ hybridization. The relationship between the expression of NF-κBp65 and the biological behavior of tumor was studied. Results: ①NF-κBp65 expression in laryngeal carcinoma and normal laryngeal mucosa between the differences were statistically significant (P <0.05). ② The high expression of NF-κBp65 correlated with cervical lymph node metastasis and clinical stage, but had no correlation with tumor location and pathological differentiation. Conclusion: NF-κBp65 is a valuable indicator to judge the prognosis of laryngeal cancer.