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卵巢早衰(POF)的病因众多,免疫功能异常是特发性POF最常见的原因。作者收集了11例POF伴不育妇女,年龄20～37岁,病程1～12年。染色体皆正常。至少2次血清LH、FSH浓度高于卵泡期水平(FSH 41～>145 IU/L,雌二醇(E_2)12～119pmol/L。超声检查无发育卵泡。其中4例伴乔本氏甲状腺类,1例伴类风湿性关节炎。1例抗DNA及IgM过高,疑免疫因素致病。故给强地松每日4次,每次25mg持续2周后停药,藉血清E_2、孕酮浓度测定及超声检查监测卵泡发育。结果2例患者血E_2水平上升,卵泡直径分别达17及20mm。其中1例自然排卵3周期,于第3周期妊娠,另1例当月妊娠。2例皆已分娩获健康活婴。此2例皆
Premature ovarian failure (POF) causes many, abnormal immune function is the most common cause of idiopathic POF. The authors collected 11 cases of infertile women with POF, aged 20 to 37 years old, duration of 1 to 12 years. Chromosomes are normal. At least two times of serum LH and FSH concentrations were higher than those of follicular phase (FSH 41 ~> 145 IU / L and E2) 12 ~ 119pmol / L. Ultrasound examination of follicles without development, 4 cases with Qorben’s thyroid , 1 case with rheumatoid arthritis.One case of anti-DNA and IgM is too high, suspected immune factors pathogenic.Therefore, to give prednisone 4 times a day, each 25mg for 2 weeks after withdrawal, by serum E_2, pregnancy Ketone concentration and ultrasound examination to monitor the follicular development.Results The blood E2 level of 2 patients increased and the diameter of follicles reached 17 and 20mm respectively.One case had 3 cycles of spontaneous ovulation and 3 cases of pregnancy and 1 case of the same month.The other two cases Have been born healthy live baby .This two cases are