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目的探讨血清降钙素原(PCT)在全身炎症反应综合征(SIRS)和多器官功能障碍综合征(MODS)发生发展中的意义及其与 SIRS/MODS 严重程度的相关性。方法选择重症监护室(ICU)危重病患者66例,在入院第1、3、5天分别测定其外周血PCT、白介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)。结果血清 PCT、IL-6及 TNF-α在 SIRS 组、MODS 组及死亡组均较非 SIRS 组、非 MODS 组及非死亡组明显升高,且 SIRS 组、MODS 组及死亡组 PCT、IL-6及 TNF-α始终维持在较高水平。组内比较,第1、3、5天血清 PCT 和 IL-6有逐步升高趋势,提示 PCT 和 IL-6与 MODS 和死亡组比 TNF-α更具有密切的相关关系。结论血清 PCT 是一个新的较为敏感的反映 SIRS/MODS 严重程度的指标,并能指导临床早期诊断和早期治疗。
Objective To investigate the significance of serum procalcitonin (PCT) in the development of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) and its relationship with the severity of SIRS / MODS. Methods Sixty - six critically ill patients in intensive care unit (ICU) were selected. The levels of PCT, IL - 6 and TNF - α in peripheral blood were measured on the 1st, 3rd and 5th day after admission. Results Serum levels of PCT, IL-6 and TNF-α in SIRS group, MODS group and death group were significantly higher than those in non-SIRS group, non-MODS group and non-death group, 6 and TNF-α always maintained at a high level. The levels of PCT and IL-6 in serum were gradually increased on the 1st, 3rd and 5th day, which suggested that PCT and IL-6 were more closely related to TNF-α than MODS and death group. Conclusions Serum PCT is a new and more sensitive indicator of the severity of SIRS / MODS and can guide the early diagnosis and early treatment of the disease.