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观察哮喘患者和正常人对抗人ＩｇＥ介导的嗜碱粒细胞释放能力和血清总ＩｇＥ的变化。结果表明：哮喘患者的嗜碱粒细胞释放能力和血清总ＩｇＥ均明显高于正常人（Ｐ＜０．０１）；哮喘患者的嗜碱粒细胞释放能力与血清总ＩｇＥ、血液嗜酸粒细胞计数均无相关性（Ｐ＞０．０５），而后两者之间却显著相关（Ｐ＜０．０１）；发现哮喘患者的嗜碱粒细胞释放能力与变应原皮肤试验有很好的符合率。提示：哮喘患者的嗜碱粒细胞释放能力异常有其内在机制。
To observe the changes of human IgE-mediated basophil release and serum total IgE in asthmatic and normal subjects. The results showed that the release of basophil and the total serum IgE of asthmatic patients were significantly higher than those of normal controls (P <0.01). The basophil release capacity of asthmatic patients was positively correlated with the serum total IgE, blood eosinophil count (P> 0.05), but there was a significant correlation between them (P <0.01). It was found that the basophil release capacity of asthmatic patients was in good agreement with that of the allergen skin test . Tip: asthma patients with abnormal basophil release capacity has its intrinsic mechanism.