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目的研究早期自然流产妇女血清中可溶性肿瘤坏死因子受体 (sTNFR)Ⅰ和Ⅱ的水平。方法应用双抗体夹心ABC -ELISA法检测孕 3月内 2 0例正常妊娠、2 0例第一次自然流产 (spon taneousabortion ,SA)和 15例反复自然流产 (recurrentspontaneousabortion ,RSA)妇女血清中的sTNFRⅠ与sTNFRⅡ。结果SA与对照组比较 ,sTNFRⅠ显著增高 (P <0 0 5 ) ;sTNFRⅠ与sTNFRⅡ在RSA中的水平较SA均有显著增高 (P <0 0 1)。结论sTNFR可能与自然流产的发生发展有关。其水平 (尤其是sTN FRⅠ )的升高就妊娠而言可能具有自我保护和自我稳定的生理意义。
Objective To study the levels of soluble tumor necrosis factor receptor (sTNFR) Ⅰ and Ⅱ in the serum of early spontaneous abortion women. Methods The serum levels of sTNFRⅠ in 20 normal pregnant women, 20 spontaneous spontaneous abortion (SA) and 15 recurrent spontaneous abortion (RSA) women were detected by ABC-ELISA. With sTNFRⅡ. Results Compared with control group, sTNFRⅠwas significantly increased in SA group (P <0.05). The levels of sTNFRⅠand sTNFRⅡin RSA group were significantly higher than those in SA group (P <0.01). Conclusion sTNFR may be related to the occurrence and development of spontaneous abortion. Elevated levels, especially sTN FRI, may have physiological implications for self-protection and self-stability in pregnancy.