论文部分内容阅读
免疫缺陷型动物对于研究肿瘤、移植及人免疫缺陷病的发病机制和药物治疗有重要意义。迄今为止,已建立起多种具有原发性免疫缺陷的近交系和突变导入系动物及多种人工诱导免疫缺陷的方法。Southam等发现新生动物(neonatal animal)有免疫缺陷,并成功地进行了人体肿瘤的异体移植。继之,又发现一些特殊解剖学部位,如大脑、仓鼠颊窝(hamster cheek pouch)眼前庭是免疫“禁区”。在这些部位同种和异种移植肿瘤易于生长。放射线照射、免疫抑制性药物如考的松、环磷酰胺等能诱导免疫抑制。1966年,
Immunodeficiency animals play an important role in studying the pathogenesis and drug therapy of tumors, transplantation and human immunodeficiency diseases. To date, many inbred lines and mutagenesis-derived animals with primary immunodeficiency have been established as well as a variety of methods for artificially induced immunodeficiency. Southam et al. Found that neonatal animals were immunodeficient and successfully performed allogeneic transplantation of human tumors. Then, it was found that some special anatomical sites, such as the brain, hamster cheek pouch (hamster cheek pouch) vestibule is immune “forbidden zone.” Homologous and xenograft tumors are prone to growth in these areas. Radiation, immunosuppressive drugs such as cortisone, cyclophosphamide, etc. can induce immune suppression. In 1966,