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应用二乙烯三胺五醋酸一钙三钠(DFPA-CaNa_3又名五醋三胺、促排灵-235)作放射性核素(超铀、稀土元素)内污的促排药物,在动物实验和人体试用中业已证明是当前较好的一个药物。治疗重金属 Pb 中毒患者,二乙烯三胺五醋酸(DFPA)的疗效显著,优于依地酸(EDTA),排 Pb 效果好,副作用小。泰勒(Taylor)和波尔拿斯-博海(Plnas-Bohne)等在实验中,发现 DTPA-CaNa_3产生的毒性与其用药方式有关。泰勒和加百特(Gabard)等观察到,毒性作用是由于排空了机体体内主要微量金属离子 Zn~(++),以致影响到脱氧核糖核酸
Application of diethylenetriamine pentaacetic acid monocalcium (DFPA-CaNa_3, also known as pentaacetic acid triazine, carbamazepine-235) as a radionuclide (transuranium, rare earth elements) within the pollution of the drug, in animal experiments and Human trials have proven to be a better drug today. Treatment of heavy metal poisoning in patients with Pb, diethylenetriamine pentaacetic acid (DFPA) a significant effect, superior to the acid (EDTA), row Pb effect is good, with little side effects. Taylor and Plnas-Bohne et al. Found that the toxicity of DTPA-CaNa_3 was related to the mode of administration. Taylor and Gabard observed that the toxic effect is due to the evacuation of Zn ~ (++), the main trace metal ion in the body, affecting DNA