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目的：探讨ＹＮＺ２２位点串联重复序列（ＶＮＴＲ）的杂合性丢失在大肠癌发生发展中的作用。方法：应用多聚酶链反应技术对４１例大肠癌ＹＮＺ２２位点的ＶＮＴＲ区进行了分析。结果：大肠癌ＹＮＺ２２位点杂合缺失（ＬＯＨ）率为４３．３％。分析ＬＯＨ与临床病理参数间的关系发现，大肠癌ＹＮＺ２２位点杂合缺失与肿瘤大小，组织学类型，淋巴结转移，浸润深度和临床分期无关。结论：ＹＮＺ２２位点杂合缺失参与了大肠癌发生与发展。
Objective: To investigate the role of loss of heterozygosity of YNZ22 locus tandem repeat (VNTR) in the development of colorectal cancer. METHODS: Polymerase chain reaction (PCR) technique was used to analyze the VNTR regions of YNZ22 locus in 41 cases of colorectal cancer. Results: The LOH rate of YNZ22 locus in colorectal cancer was 43.3%. Analysis of the relationship between LOH and clinicopathological parameters revealed that the loss of heterozygous YNZ22 locus in colorectal cancer was not associated with tumor size, histological type, lymph node metastasis, depth of invasion, and clinical stage. Conclusion: Loss of heterozygous YNZ22 locus participates in the occurrence and development of colorectal cancer.