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第Ⅴ类药物一、异搏定(Verapamil,Isoptine,1962年)(一)药理作用阻滞细胞膜的钙离子通道,抑制窦房结和房室结的自律性,延长房室结传导(A-H间期延长),使单向阻滞转为双向阻滞而阻断折返激动,扩张冠状动脉和周围血管,抑制心肌收缩力.(二)适应证室上性异位心律转复为窦性心律(如室上性心动过速)或减慢心室率(如心房扑动或颤动);窦性心动过速;偶用于室性心律失常。(三)禁忌证心力衰竭、不稳定的房室传导阻滞、病态窦房结综合征、心源性休克、其他低血压
Class Ⅴ drugs verapamil (Isoptine, 1962) (A) Pharmacological effects block cell membrane calcium channels, inhibition of sinus node and atrioventricular node autonomy, to extend the atrioventricular node conduction (AH Term extension), so that the unidirectional block into two-way block and block the reentry stimulation, expansion of coronary and peripheral blood vessels, inhibition of myocardial contractility. (2) Indications of supraventricular ectopic rhythm of sinus rhythm ( Such as supraventricular tachycardia) or slow down the ventricular rate (such as atrial flutter or fibrillation); sinus tachycardia; even used for ventricular arrhythmias. (C) contraindications heart failure, unstable atrioventricular block, sick sinus syndrome, cardiogenic shock, other hypotension