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目的:探讨嗜酸粒细胞阳离子蛋白(ECP)在鼻内镜鼻腔黏膜转归过程中表达变化的规律。方法:采用酶免疫荧光分析技术检测ECP在10例Ⅰ型、Ⅱ型慢性鼻窦炎患者功能性鼻窦开放术后术腔黏膜恢复过程中的表达变化。结果:ECP蛋白在正常鼻黏膜中少量表达,而在慢性鼻窦炎黏膜或息肉中明显升高,且随时间呈现如下变化规律:①术后1~2周较术前明显降低(P<0.01);②术后4~6周达高峰,基本恢复至术前水平;③术后10~12周回落,接近于术后1~2周水平。结论:ECP在术后4~6周表达明显增高,提示其可能参与延迟内镜鼻窦鼻腔黏膜上皮化的进程。
Objective: To investigate the regularity of eosinophil cationic protein (ECP) expression during nasal endoscopic nasal mucosa. Methods: The expression of ECP in 10 patients with type Ⅰ and type Ⅱ chronic sinusitis after functional open sinus surgery was detected by enzyme immunofluorescence assay. Results: ECP protein was slightly expressed in normal nasal mucosa and significantly increased in mucosa or polyps of chronic sinusitis, and showed the following changes as time went by: (1) The levels of ECP were significantly decreased 1 ~ 2 weeks after operation (P <0.01) ; (2) peaked at 4 to 6 weeks postoperatively, and returned to the preoperative level basically; (3) decreased from 10 to 12 weeks after operation, close to the level of 1 to 2 weeks postoperatively. Conclusion: The expression of ECP in 4 ~ 6 weeks after operation is significantly increased, suggesting that it may be involved in the delayed endoscopic sinus nasal mucosa epithelialization process.