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目的:观察温中散寒汤加减联合常规三联疗法治疗消化性溃疡的效果。方法:选取96例消化性溃疡患者作为研究对象,将患者随机分为对照组和观察组各48例,对照组予常规三联疗法治疗,观察组在对照组治疗基础上予以温中散寒汤加减治疗,行中医症状评分,统计临床疗效、幽门螺杆菌(Hp)根除率、复发率及不良用药反应发生率。结果:观察组总有效率为91.67%,与对照组的77.08%相比,差异有统计学意义(P<0.05)。治疗后,2组腹痛、烧心、反酸、嗳气症状评分均低于治疗前(P<0.05);观察组各项症状评分与对照组相比,差异均有统计学意义(P<0.05)。观察组Hp根除率及1年复发率分别为89.58%、8.33%,与对照组的72.92%、25.00%相比,差异均有统计学意义(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:温中散寒汤加减联合常规三联疗法治疗消化性溃疡可有效缓解患者的临床症状,提高Hp根除率,降低疾病复发率。
Objective: To observe the effect of Wen Zhong San Han Tang combined with conventional triple therapy on peptic ulcer. Methods: Ninety-six patients with peptic ulcer were selected as study object. The patients were randomly divided into control group and observation group, with 48 cases in each group. The control group was treated with conventional triple therapy. The observation group was treated with Wenzhong Sanhan Decoction Treatment, Chinese medicine symptom score, statistical clinical efficacy, Helicobacter pylori (Hp) eradication rate, recurrence rate and incidence of adverse drug reactions. Results: The total effective rate in the observation group was 91.67%, which was significantly different from that in the control group (77.08%) (P <0.05). After treatment, the scores of abdominal pain, heartburn, acid reflux and belching were all lower than those before treatment (P <0.05). The score of each symptom in the observation group was statistically significant compared with the control group (P <0.05). The Hp eradication rate and one-year recurrence rate in the observation group were 89.58% and 8.33%, respectively, which were significantly different from those in the control group (72.92% and 25.00%, P <0.05). The incidence of adverse reactions in the two groups, the difference was not statistically significant (P> 0.05). Conclusion: Wenzhong Sanqian Decoction combined with conventional triple therapy for peptic ulcer can effectively alleviate the clinical symptoms, improve the Hp eradication rate and reduce the recurrence rate.