局部用氨基糖苷类和第一代头孢菌素的复合制剂是开始治疗可能的细菌性角膜炎主要局部用制剂。但是由于对氨基糖苷类产生耐药性的绿脓杆菌普遍增加,并认识到局部应用氨基糖苷类的毒性,及作为角膜炎致病菌草绿色链球菌的出现,均刺激研究更有效、低毒的局部用抗菌剂。氟喹诺酮类药物对常见的角膜炎病原菌金葡菌、草绿色链球菌等革兰氏阳性菌和绿脓杆菌等革兰氏阴性菌均有极好活性。因为它们的作用机理是对前核细胞DNA超螺旋作用,因此氟喹诺酮类药物对真核状态的人 Topical aminoglycosides and first-generation cephalosporins in combination formulations are among the top topical preparations for the treatment of possible bacterial keratitis. However, due to the general increase in aminoglycoside-resistant Pseudomonas aeruginosa and the recognition of the topical application of aminoglycoside toxicity and the emergence of S. aureus, a causative pathogen of keratitis, stimulating research is more effective and less toxic Topical antimicrobials. Fluoroquinolones have excellent activity against the common keratitis pathogens Staphylococcus aureus, Gram-positive bacteria such as Streptococcus viridans, and gram-negative bacteria such as Pseudomonas aeruginosa. Because of their mechanism of action is pre-nucleus DNA supercoiled, so fluoroquinolones on eukaryotic human