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目的探讨食用含三聚氰胺奶粉的婴幼儿发生泌尿系结石的危险因素。方法收集2008年9月14日～2009年1月6日在兰州大学第二医院进行免费筛查的食用含三聚氰胺奶粉的婴幼儿病历,根据发生结石的病例数按1︰l比例从无泌尿系结石的婴幼儿中随机抽取对照组,采用logistic回归模型对泌尿系结石的危险因素进行单因素和多因素分析。结果结石组647例,对照组647例,男678例,女616例,平均年龄19.27月。食用高三聚氰胺含量的三鹿奶粉婴幼儿发生泌尿系结石的OR为6.09(P<0.01),其中婴儿性别为男、人工喂养的OR值分别为1.39(P<0.01)和1.61(P<0.01)。随着年龄增长发生结石的风险逐渐下降,<6月、6月～、12月～婴幼儿发生结石的OR值分别是5.23(P<0.01)、2.73(P<0.01)、1.60(P<0.01)。随着食用含三聚氰胺奶粉时间的延长,发生结石的风险逐渐增加。食用含三聚氰胺奶粉3个月～、6个月～、12个月～婴幼儿发生结石的OR值分别是2.10(P<0.01)、2.81(P<0.01)、4.75(P<0.01)。结论食用高三聚氰胺含量奶粉(三鹿奶粉)、人工喂养和男性是婴幼儿发生泌尿系结石的危险因素,食用含三聚氰胺奶粉时间越长、年龄越小,发生泌尿系结石的风险越高。
Objective To investigate the risk factors of urolithiasis in infants and children with melamine milk powder. Methods The records of infants and young children with melamine milk powder who were screened free of charge at the Second Hospital of Lanzhou University from September 14, 2008 to January 6, 2009 were collected according to the ratio of 1: 1 without urinary tract The control group was randomly selected from infants and toddlers with stones. The risk factors of urolithiasis were analyzed by single factor and multivariate logistic regression models. Results The stone group of 647 cases, the control group of 647 cases, 678 males and 616 females, with an average age of 19.27 months. The odds of urolithiasis in infants and young children with Sanlu milk powder with high melamine content were 6.09 (P <0.01). The odds ratios for male and female infants were 1.39 (P <0.01) and 1.61 (P <0.01) . The risk of developing stones decreased with age. The OR values of stones in infants and young children between June and June ~ December were 5.23 (P <0.01), 2.73 (P <0.01) and 1.60 (P <0.01) ). With the extended consumption of melamine-containing milk powder, the risk of developing stones gradually increases. The odds ratios of stones with melamine milk powder in 3 months ~ 6 months ~ 12 months ~ infant were 2.10 (P <0.01), 2.81 (P <0.01), 4.75 (P <0.01) respectively. Conclusion High melamine milk powder (Sanlu milk powder), artificial feeding and males are the risk factors for urolithiasis in infants and children. The longer the melamine milk powder is eaten, the younger the patients and the higher the risk of urolithiasis.