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目的了解三级甲等医院住院高血压患者降压药的药物利用情况,促进抗高血压药物的合理使用。方法自辽宁省两城市方便抽样选择4家三级甲等医院,随机选取2011年1月1日—2016年1月1日高血压住院患者8 000例,提取病历中抗高血压药物信息,分析抗高血压药物利用情况。结果抗高血压药物使用例次最多的为氨氯地平8.49%(2 055/24 192),用药频度最高的抗高血压药物是缬沙坦(31 391.85),DUI值最大的抗高血压药物是缬沙坦氨氯地平(1.63),DUI值最小的抗高血压药物是咪达普利(0.75),DUI值接近1.0的抗高血压药物分别是氯沙坦(0.98)、尼卡地平(0.99)、美托洛尔(1.01)、厄贝沙坦(1.02)、厄贝沙坦氢氯噻嗪(1.03)。结论辽宁两城市高血压住院患者抗高血压药物利用较合理。
Objective To understand the use of antihypertensive drugs in hospitalized patients with hypertension in Grade Three First Class hospitals and to promote the rational use of antihypertensive drugs. Methods Four Grade-3 Hospitals were randomly selected from two cities in Liaoning Province by random sampling from January 1, 2011 to January 1, 2016, 8,000 inpatients with hypertension and antihypertensive drug information was extracted from the medical records Antihypertensive drug use. Results The most frequently used antihypertensive drugs were amlodipine 8.49% (2 055/24 192). The most frequently used antihypertensive drugs were valsartan (31 391.85), antihypertensives with the highest DUI value Is valsartan amlodipine (1.63), antihypertensives with the lowest DUI values are imidapril (0.75) and antihypertensives with DUI values close to 1.0 are losartan (0.98), nicardipine 0.99), metoprolol (1.01), irbesartan (1.02) and irbesartan hydrochlorothiazide (1.03). Conclusion The utilization of antihypertensive drugs in patients with hypertension in two cities of Liaoning Province is reasonable.