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免疫抑制剂环孢菌素 A(CYA)是由真菌产生的一种环十一肽。自从1978年 Calae 等在临床上用于肾移植以求,CYA 使脏器移植的成功率明显提高。1986年得到日本厚生省许可,并在临床上广泛应用。最近发现 CYA 可促进小鼠胸腺淋巴瘤、大鼠肠道腺癌的发生,介绍如下。CYA 的免疫抑制机理尚不清楚,一般认为抑制对T 淋巴细胞依赖性免疫应答所必需的抗原刺激信号。CYA 与过去的免疫抑制剂不同,对骨髓的毒性低,而对实验动物和人的肾脏有毒性作用。最近 Shinzuka 等开始给小鼠腹腔注射 N-甲基-N-亚硝基脲(MNu)25mg/kg 体重,然后,给予含0.015%CYA 的饲料20周。结果表明,CYA 能促进胸腺淋巴瘤的发生,其发生率在 MNu 组为2/22(9%),在
The immunosuppressant cyclosporin A (CYA) is a cyclodextrin produced by a fungus. Since 1978, Calae and other clinically used in kidney transplantation in order to CYA organ transplantation significantly increased the success rate. In 1986 the Japanese Ministry of Health and permission, and widely used in clinical practice. Recently found that CYA can promote mouse thymic lymphoma, intestinal adenocarcinoma of rats, described below. The mechanism of immunosuppression of CYA is not clear, generally considered to suppress the T lymphocyte-dependent immune response required for antigen-stimulating signals. Unlike previous immunosuppressive agents, CYA has low toxicity to bone marrow and toxic effects on experimental animals and human kidneys. Recently, Shinzuka et al. Started intraperitoneal injection of 25 mg / kg body weight of N-methyl-N-nitrosourea (MNu), followed by administration of 0.015% CYA for 20 weeks. The results showed that, CYA can promote the incidence of thymic lymphoma, the incidence of MNu group was 2/22 (9%), at