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目的探讨自拟糖肾方联合氯沙坦钾治疗糖尿病肾病患者的临床疗效和安全性。方法选取2014年9月至2015年12月广东省中西医结合医院收治的糖尿病肾病(DN)患者(气阴两虚、湿瘀阻络证)60例,随机分为对照组和观察组,各30例。对照组给予基础西药治疗,观察组在对照组基础上加用自拟糖肾方。治疗结束后比较两组患者临床疗效及各项化验指标改善情况。结果观察组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后,观察组患者血清尿素氮(BUN)、血肌酐(SCr)、单核细胞趋化蛋白-1(MCP-1)和尿白蛋白排泄率(UAER)水平均明显低于对照组,差异均有统计学意义(均P<0.05);两组患者糖化血红蛋白(Hb Alc)及C反应蛋白(CRP)治疗前后比较差异均无统计学意义(均P>0.05)。结论自拟糖肾方联合氯沙坦钾组治疗DN的综合疗效优于单纯氯沙坦钾组,可有效改善患者肾脏功能,降低炎性因子水平。
Objective To investigate the clinical efficacy and safety of self-made Tangshen Decoction combined with losartan potassium in the treatment of diabetic nephropathy. Methods Sixty patients with diabetic nephropathy (DN) admitted from Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine from September 2014 to December 2015 were randomly divided into control group and observation group 30 cases. The control group was given basic western medicine. The observation group was given self-made Tangshen recipe on the basis of the control group. After treatment, the clinical efficacy and the improvement of various laboratory indexes were compared between the two groups. Results The total effective rate of observation group was significantly higher than that of control group (P <0.05). After treatment, serum urea nitrogen (BUN), serum creatinine (SCr), monocyte chemotaxis The levels of MCP-1 and urinary albumin excretion (UAER) were significantly lower than those of the control group (all P <0.05). The Hb Alc and C responses Protein (CRP) before and after treatment were no significant difference (all P> 0.05). CONCLUSION: The combined therapy of Tangshen Decoction and losartan potassium group is better than losartan potassium alone, which can effectively improve renal function and reduce the level of inflammatory cytokines.