论文部分内容阅读
为探讨铅的生殖毒性，研究了小鼠睾丸的脂质过氧化作用。将动物分为３组，对照组（Ⅰ），（１５ｍｇ／ｋｇ）（Ⅱ）和３０ｍｇ／ｋｇ（Ⅲ）铅染毒组，腹腔注射染毒１１次。结果表明，染毒组体重明显降低，血铅浓度比对照组增加１５０～２１０倍，骨铅增加７７～１０倍。Ⅰ、Ⅱ、Ⅲ组的睾丸ＴＳＯＤ分别为４０、３２、２４Ｎｕ／ｍｌ，差异具有显著性。血铅与睾丸ＴＳＯＤ有显著的负相关。睾丸ＧＳＨｐｘ也有明显改变。血浆维生素Ｃ和睾丸ＭＤＡ随着铅染毒剂量增加而有降低倾向。因此，脂质过氧化是铅导致生殖腺损伤的机理之一。
To explore the reproductive toxicity of lead, lipid peroxidation in mouse testis was studied. The animals were divided into 3 groups: control group (Ⅰ), (15mg / kg) (Ⅱ) and 30mg / kg (Ⅲ) lead poisoning group. The results showed that the body weight of the exposed group was significantly lower, blood lead concentration increased 150 ~ 210 times than the control group, bone lead increased 7 7 ~ 10 times. The TSOD of testis in group Ⅰ, Ⅱ and Ⅲ were 40, 32 and 24Nu / ml, respectively, with significant difference. Blood lead and testicular TSOD significant negative correlation. Testicular GSH px also significantly changed. Plasma vitamin C and testicular MDA decreased with the increase of lead exposure dose. Lipid peroxidation is therefore one of the mechanisms by which lead causes gonadal injury.