论文部分内容阅读
目的探讨内皮素(ET)及降钙素基因相关肽(CGRP)在类风湿性关节炎(RA)发生、发展过程中的作用。方法采用放射免疫分析法,对30例RA患者及20例正常对照组血浆中ET及CGRP的水平进行检测。结果RA患者血浆中ET的水平及ET/CGRP的比值明显升高,CGRP水平明显降低,与正常对照组相比较差异显著(P<0.01)。进一步分析表明,活动期RA患者及关节X线改变为Ⅲ～Ⅳ期的RA患者,血浆ET的水平及ET/CGRP的比值明显高于稳定期及关节改变为Ⅰ～Ⅱ期的RA患者;而血浆CGRP的水平明显低于后者(P<0.01)。结论RA患者体内存在明显地ET及CGRP的平衡失调,且与RA患者的病情严重程度密切相关,提示ET及CGRP参与了RA的发病过程。
Objective To investigate the role of endothelin (ET) and calcitonin gene related peptide (CGRP) in the development and progression of rheumatoid arthritis (RA). Methods The levels of plasma ET and CGRP in 30 patients with RA and 20 normal controls were measured by radioimmunoassay. Results The plasma levels of ET and ET / CGRP in RA patients were significantly higher than those in normal controls (P <0.01). Further analysis showed that the level of ET and the ratio of ET / CGRP were significantly higher in active RA patients and RA patients with stage III-IV arthritis than that in RA patients with stable and joint changes of stage Ⅰ-Ⅱ; Plasma CGRP levels were significantly lower than the latter (P <0.01). Conclusion There is a clear imbalance of ET and CGRP in patients with RA, which is closely related to the severity of RA. It suggests that ET and CGRP are involved in the pathogenesis of RA.