miRNAs是一类进化上保守的非编码小RNA,能在转录后水平对靶mRNAs进行降解或翻译抑制,在多种生物学过程中发挥重要调节作用。哺乳动物的免疫系统在抵抗感染、自身稳定和免疫监视方面发挥重要作用。为达到免疫应答和免疫耐受的恰当平衡,免疫反应的起始、终止和反应强度必须被严谨 MiRNAs are a class of evolutionarily conserved, non-coding small RNAs that are capable of degrading or silencing target mRNAs at post-transcriptional levels and play important regulatory roles in a variety of biological processes. Mammalian immune systems play an important role in fighting infection, stabilizing themselves and monitoring immunity. In order to achieve the proper balance of immune response and immune tolerance, the onset, termination and intensity of the immune response must be rigorously