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鞘内注射氨甲喋呤（MTX）广泛用于白血病患儿的中枢神经系统白血病（CNSL）预防，但同时也可引起少数毒性反应，我科对1974年至1996年间住院的白血病患儿219例进行鞘内注射MTX1096人次所发生的毒性反应做了细致的观察，总结如下：临床资料住院患儿219例，其中男126例，占57．5
Intrathecal methotrexate (MTX) is widely used in the prevention of central nervous system leukemia (CNSL) in children with leukemia, but it can also cause a few toxic reactions. In our department, 219 patients with leukemia hospitalized between 1974 and 1996 were treated with intrathecal drugs. The toxicity of MTX1096 injections was carefully observed and summarized as follows: Clinical data: 219 cases of hospitalized children, including 126 males, accounting for 57.5