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用奥曲肽（ｓａｎｄｏｓｔａｔｉｎ）治疗５例活动性肢端肥大症，疗程６个月．奥曲肽剂量４５０～１５００μｇ／日，分次皮下注射。治疗后头痛、软组织肿胀等症状明显减轻。４例病人血清ＧＨ水平平均下降５０％以上，１例无下降。４例垂体瘤体积稍缩小。治疗后糖尿病好转１例，１例出现糖耐量异常。另１例出现胆囊结石，停药１年后随诊，胆结石消失。结果提示奥曲肽能有效地降低血清ＧＨ水平，改善临床症状。对药物的副作用应作进一步观察。
Five cases of active acromegaly were treated with sandostatin for 6 months. The dosage of octreotide 450 ~ 1500μg / day, sub-subcutaneous injection. After treatment headache, soft tissue swelling and other symptoms significantly reduced. Serum GH levels in 4 patients dropped by more than 50% on average, while none in 1 patient decreased. 4 cases of pituitary tumor size slightly smaller. 1 case of diabetic patients improved after treatment, 1 case of impaired glucose tolerance. Another case of gallstones, withdrawal 1 year follow-up, gallstone disappeared. The results suggest that octreotide can effectively reduce serum GH levels and improve clinical symptoms. The side effects of drugs should be further observed.