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采用自动惊厥测定仪测定狼毒大戟、天南星、白蔹提取物的抗电刺激皮层惊厥阈值和抗戊四唑惊厥作用的结果。3种中药提取物以10ml/kg(相当于原生药1.2g/kg)腹腔注射。结果:给药后狼毒大戟组惊厥阈值提高(118±29)μA,效果持续10天;天南星组提高(119±22)μA,效果持续7天;白蔹组提高(83±19)μA,效果持续5天。抗戊四唑惊厥实验:对照组的惊厥潜伏期为3.5min,狠毒大戟为7.5min,天南星为7.4min,白蔹为6.8min。除给药当天动物有轻度镇静作用外,未见其他毒副作用。实验结果提示3种药提取物不但有明显的抗惊厥作用(P<0.001),而且药效持续较久。
The anticonvulsive threshold for anticonvulsant activity and the anticonvulsant effect of pentylenetetrazol in the extracts of Stellera philoxeroides, Arisaema, and Angelica were determined by an automatic convulsion analyzer. Three kinds of Chinese herbal extracts were intraperitoneally injected with 10 ml/kg (corresponding to 1.2 g/kg of probiotics). Results: The concentration of seizures in the stellera blume group increased by (118±29)μA for 10 days after drug administration, while that in the treatment group increased by (119±22) μA for 7 days, and that in the group of white peony increased by (83±19) μA. The effect lasts 5 days. Anti-pentylenetetrazol convulsions test: The convulsive incubation period of the control group was 3.5 min, the scorpion scorpion was 7.5 min, the argentinian was 7.4 min, and the peony was 6.8 min. Except for mild sedation of animals on the day of dosing, no other side effects were observed. The experimental results suggest that the three drug extracts not only have significant anticonvulsant effects (P<0.001), but also have long-lasting efficacy.