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目的 :比较奈替米星 (Net)与阿米卡星 (Ami)在下呼吸道细菌性感染疾病中的疗效及不良反应。方法 :对痰细菌培养有致病菌生长的 16 0例患者随机分成 2组 ,分别用 Net30 0 mg或 Am i40 0 m g,iv gtt,qd,疗程 7~ 10 d。结果 :Net组有效率(87.5 % )明显高于 Am i组 (6 6 .2 % ) ,辅助检查中白细胞及分类恢复正常率、胸片恢复正常率和痰菌转阴率 ,前组均高于后组 ,而不良反应发生率前组低于后组。结论 :Net治疗下呼吸道感染的疗效优于 Am i,且不良反应也较少。
PURPOSE: To compare the efficacy and side effects of Net and Ami in bacterial infections of lower respiratory tract. Methods: One hundred and sixty patients with sputum bacterial growth were randomly divided into two groups: Net30 0 mg or Am40 o m g, iv gtt qd for 7-10 days. Results: The effective rate (87.5%) in the Net group was significantly higher than that in the Am i group (66.2%), the normal white blood cell count and classification recovery rate, the recovery rate of the chest X-ray and the negative conversion rate of sputum were higher in the former group In the latter group, while the incidence of adverse reactions in the former group was lower than the latter group. Conclusion: Net treatment of lower respiratory tract infection is superior to Am i with fewer adverse reactions.