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Objective:To explore the relationship between polymorphism of PAI-1 gene and type 2 diabetes mellitus(DM} , hyperten-sion, and coronary heart disease. Methods: The polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene was analyzed by PCRtechnique in 281 subjects. Results: The frequency uf 4G/ 4G genotype and 4G allele uf PAI- 1 in type 2 diabetic patients were in-creased compared with non-diabetic subjects(X2 = 6. 0 and 6. 3 respectively,P<0. 05). In DM group, the frequency of 4G/4.G geno-type and 4G allele of PAI-1 in patients with coronary heart disease were significantly increased than in patients without coronary heart dis-ease (X2 = 6. 9 and 7. 6 respectively,P<0. 05 ,P<0. 01 respecitively). In the model uf multiple factors non-conditional logistic re-gression analyses,coronary lieart disease related to age, obesity ard ’polymorphism of PAI-1(P<0. 001, P<0. 05,P<0. 01 respec-tively). Conclusion :These results suggested that the 4G allele uf PAI-1 gene might be a risk factor of type 2 diabe
Objective: To explore the relationship between polymorphism of PAI-1 gene and type 2 diabetes mellitus (DM}, hyperten-sion, and coronary heart disease. Methods: The polymorphism of plasminogen activator inhibitor-1 PCR technique in 281 subjects. Results: The frequency uf 4G / 4G genotype and 4G allele uf PAI-1 in type 2 diabetic patients were in-creased compared with non-diabetic subjects (X2 = 6.0 and 6.3 respectively, P < 0.05). In DM group, the frequency of 4G / 4.G geno-type and 4G allele of PAI-1 in patients with coronary heart disease were significantly increased than in patients without coronary heart dis-ease (X2 = 6. P <0.01 respecitively). In the model uf multiple factors non-conditional logistic re-regression analyzes, coronary lieart disease related to age, obesity ard ’polymorphism of PAI- 1 (P <0.001, P <0.05, P <0.01 respec-tively). Conclusion: These results suggest that the 4G allele uf PAI-1 gene might be a risk fact or of type 2 diabe