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目的 :研究帕金森病 (PD)患者认知功能损害。方法 :选取PD患者进行临床痴呆评分与简易智能测定 ,按照其结果将PD患者分为认知障碍组与认知正常组 ,分别进行事件相关电位检测 ,进行比较。结果 :PD认知正常组较正常对照组N2 、P3潜伏期延长 ,PD认知障碍组较PD认知正常组P3潜伏期延长。PD患者P3潜伏期与MMSE呈负相关 (r=- 0 41 5)。结论 :PD患者P3潜伏期延长 ,P3、MMSE均可反映PD患者的认知状况
Objective: To study the cognitive impairment in patients with Parkinson’s disease (PD). Methods: Patients with PD were selected for clinical dementia score and simple intelligence test. According to the results, PD patients were divided into cognitive impairment group and normal cognitive group. Event-related potentials were detected and compared. Results: The latent period of N2 and P3 in the normal cognitive group of PD was prolonged, and the latent period of P3 was longer in PD cognitive impairment group than in normal cognitive group of PD. The latency of P3 in PD patients was negatively correlated with MMSE (r = - 0 41 5). Conclusion: P3 patients with PD prolonged latency, P3, MMSE can reflect the cognitive status of patients with PD