论文部分内容阅读
目的观察选择性COX-2抑制剂NS-398对鼠实验性结肠癌的防治作用,并探讨其可能的作用机制。方法采用1,2-二甲肼(DMH)+右旋葡聚糖苷钠(DSS)诱导大鼠结肠癌。实验分3组:对照组、奥沙利铂干预组及NS-398干预组,观察各组大鼠结肠异常增生隐窝灶(ACF)数量及结肠癌的发生率并检测肿瘤组织微血管密度(MVD)。结果(1)干预组诱导出ACF数量及结肠癌发生率明显低于对照组(P<0.05)。(2)干预组瘤组织中MVD较对照组明显减少(P<0.05)。结论(1)COX-2抑制剂NS-398可以通过阻断肿瘤血管形成,达到抑制大鼠结肠肿瘤形成的目的。(2)NS-398抗鼠结肠癌作用与化疗药物奥沙利铂相当。
Objective To observe the preventive and therapeutic effects of NS-398, a selective COX-2 inhibitor, on experimental colon cancer in rats and to explore its possible mechanism. Methods Colon cancer was induced by 1, 2-dimethylhydrazine (DMH) + dextran sodium (DSS) in rats. The experiment was divided into three groups: the control group, the oxaliplatin intervention group and the NS-398 intervention group. The numbers of colorectal cryptosis (ACF) and the incidence of colon cancer in each group were observed and the microvessel density (MVD) ). Results (1) The number of induced ACF and the incidence of colon cancer in the intervention group were significantly lower than those in the control group (P <0.05). (2) MVD in intervention group was significantly lower than that in control group (P <0.05). Conclusions (1) NS-398, a COX-2 inhibitor, can inhibit the formation of colonic tumors in rats by blocking tumor angiogenesis. (2) NS-398 anti-rat colon cancer effect and chemotherapy drug oxaliplatin quite.