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为研究溃疡样型功能性消化不良 (FD)食管下端的酸敏感性及病理性胃食管反流 ,对 5 3例溃疡样型 FD患者及 2 0例健康对照者进行了食管的酸敏感性测定 ,其中 4 7例 FD和 16例对照者又接受了 2 4小时动态 p H检测。结果显示 67.9%溃疡样型 FD患者酸刺激呈阳性 ,4 2 .5 %溃疡样型 FD患者有病理性胃食管反流 ,显著高于对照组 (P<0 .0 1)。显示食管下端酸敏感性的增高和病理性胃食管反流可能是疼痛性 FD发病的病理生理机制之一
To study the acid sensitivity and pathologic gastroesophageal reflux in the lower esophagus of functional ulcer-type dyspepsia (FD), esophageal acid sensitivity assay was performed in 53 patients with ulcer-like FD and 20 healthy controls , Of which 47 cases of FD and 16 controls also received 24 hours dynamic p H test. The results showed that 67.9% of patients with ulcer-like FD were acid-stimulated, and 42.2% of patients with ulcer-like FD had pathologic gastroesophageal reflux, which was significantly higher than that of the control group (P <0.01). Increased acid sensitivity and pathologic gastroesophageal reflux at the lower end of the esophagus may be one of the pathophysiological mechanisms of painful FD disease