目的 探讨早期颅骨修补术对颅脑外伤术后颅骨损伤的治疗效果?方法 对我院2015年12月至2017年12月收治的84例颅脑外伤术后颅脑损伤患者进行研究，根据手术时机分成例数均等的对照组和观察组，分别予以晚期颅骨修补术(术后3个月后)和早期颅骨修补术(术后1~3个月内)，进行两组疾病治疗效果?并发症发生率和生活质量的对比?结果 观察组疾病治疗总有效率为78.57%，与对照组临床疗效(54.76%)相比，所得数据间存在显著性差异(P<0.05);对照组和观察组患者在本次研究中出现并发症的概率分别为28.57%和“,”Objective To explore the therapeutic effect of early cranioplasty on craniocerebral injury after craniocerebral trauma. Methods Eighty-four patients with craniocerebral injury after craniocerebral trauma treated in our hospital from December 2015 to December 2017 were studied. The patients were divided into control group and observation group according to the timing of operation. Late skull repair (3 months after operation) and early skull repair (within 1-3 months after operation) were performed respectively. the therapeutic effect， incidence of complications and quality of life were compared between the two groups. Results The total effective rate of disease treatment in the observation group was 78.57%. Compared with the clinical efficacy of the control group (54.76%)， there was significant statistical difference between the data obtained (P <0.05). The probability of complications in the control group and theobservation group were 28.57% and 9.52% respectively in this study， with significant statistical differences between the study data (P <0.05). the scores of all dimensions of the quality of life of the observation group were higher than those of the control group， and there were significant differences between the data (P <0.05). Conclusion Early cranioplasty for the treatment of skull defects after craniocerebral trauma can significantly improve the therapeutic effect of the disease， reduce the occurrence of complications， and significantly improve the quality of life of patients. It is worth further expanding the application scope.