目的研究黄芩煎剂对大鼠实验性肝损伤的保护作用及其机制。方法采用急性CCl4 肝损伤模型 ,设黄芩煎剂大、中、小剂量组、对照组和正常组 ,观察各组大鼠血浆中丙二醛 (MDA)含量、超氧化物歧化酶 (SOD)和山梨醇脱氢酶 (SDH)活性变化。结果黄芩煎剂能降低血MDA含量和SDH活性 ,增加SOD活性 ,减轻肝损伤程度 ,且有明显的量效关系。结论黄芩煎剂具有良好的保护CCl4 致大鼠急性肝损伤的作用 ,其机理可能与抑制体内的过氧化反应有关 Objective To study the protective effect of Huangqi decoction on experimental liver injury in rats and its mechanism. Methods The acute CCl4 liver injury model was used. The large, medium and small doses of Huangqi decoction group, the control group and the normal group were set up. The content of malondialdehyde (MDA), superoxide dismutase (SOD) and plasma were observed in rats in each group. Sorbitol dehydrogenase (SDH) activity changes. Results Huangqi decoction can reduce blood MDA content and SDH activity, increase SOD activity, reduce the degree of liver injury, and there is a clear dose-effect relationship. Conclusion Huangqi decoction has a good protective effect on acute liver injury induced by CCl4 in rats, and its mechanism may be related to the inhibition of peroxidation in vivo.