动物实验证明,冰片对早期妊娠无明显引产作用;对中、晚期妊娠小鼠具有明显作用。在动物实验结果基础上,选用阴道栓剂作为给药途经。同时还采用正交法,对制备栓剂的基质进行选择。结果认为,水溶性基质加适量表面活性剂,有利于冰片的释放。 Animal experiments have shown that borneol has no significant induction of labor in early pregnancy; it has a significant effect on middle- and late-term pregnant mice. Based on the results of animal experiments, vaginal suppositories were used as a route of administration. Orthogonal methods are also used to select the matrix from which the suppository is prepared. The results suggest that the addition of a suitable amount of surfactant to the water-soluble matrix is ​​beneficial to the release of borneol.