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近年来,预防龋齿、脱敏镇痛、消炎止血、除牙石和牙锈等药物牙膏陆续上市,为保障人们使用的安全性,需要建立一系列安全性试验评价方法。我们选用JX药物牙膏,用75%的乙醇作为阳性对照物,进行了急性接触、重复接触的口腔黏膜刺激性试验[1],并探讨了该方法的可行性。1材料和方法1.
In recent years, the prevention of dental caries, desensitization and analgesia, anti-inflammatory and hemostatic drugs such as toothpaste and toothpaste are listed one after another. In order to ensure the safety of people’s use, a series of safety test evaluation methods need to be established. We chose JX toothpaste, with 75% ethanol as the positive control, the acute contact, repeated exposure to oral mucosal irritation [1], and discussed the feasibility of the method. 1 Materials and methods 1.