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用罗格列酮(RSG)处理果糖诱导的胰岛素抵抗(IR)大鼠,探讨其对血管内皮细胞(VEC)内分泌功能的作用。结果表明RSG可改善IR大鼠VEC内分泌功能,可能是通过提高主动脉一氧化氮合酶活性和机体抗氧化应激所致。
Fructose-induced insulin resistance (IR) rats were treated with rosiglitazone (RSG) to investigate their effect on endocrine function of vascular endothelial cells (VECs). The results showed that RSG can improve the endocrine function of VEC in IR rats, which may be caused by the activity of aorta nitric oxide synthase and the body’s antioxidant stress.