In this paper,we present a novel,reliable and sensitive electrochemical sensor for the determination of paracetamol based on hollow carbon Co3O4 nanosheets/reduced graphene oxide composite (Co3O4/r-GO).The Co3O4/r-GO was prepared via a rapid one-step microwave solvothermal process.Some series of techniques that included scanning electron microscopy,X-ray diffraction and Raman were carried out to characterize the morphology and structure of as-prepared materials.Most importantly,the developed electrochemical sensor exhibited a wide linear range of 0.05 to 900.0 μM and a low detection limit of 14.0 nM (S/N =3) by using differential pulse voltammetry.Furthermore,the selectivity,repeatability,stability and practical applicability were further studied with satisfactory results.