目的　探讨痢疾杆菌L型的致病作用。方法　将痢疾杆菌诱导为稳定L型 ,用灌胃法感染C57BL/ 6小鼠 ,观察小鼠的发病情况 ,并对死亡小鼠行细菌L型分离及组织学检查。本试验共分三组 :A组原菌组 ,B组L型组 ,C组生理盐水组。结果　A、B两组对小鼠均有致病性 ,以全身中毒症状为主 ,没有腹泻症状 ,B组较A组发病慢 ,症状轻 ,组织学检查无明显差异 ,两组均于肠腔中分离出相应菌。结论　痢疾杆菌L型仍有致病性 ,致病能力较原菌弱。 Objective To investigate the pathogenic role of Shigella dysenteriae L type. Methods Shigella dysenteriae was induced to stable L type. C57BL / 6 mice were infected by gavage. The incidence of mice was observed, and the mice were killed for L type separation and histological examination. This experiment is divided into three groups: group A, the original bacteria group, group B, L group, group C, saline group. Results The mice in group A and group B were all pathogenic, with symptoms of systemic poisoning and no diarrhea. The incidence of group B was slower than that of group A, and the symptoms were mild. There was no significant difference in histological examination between the two groups. In the corresponding isolated bacteria. Conclusion Shigella dysenteriae L type is still pathogenic, pathogenic ability is weaker than the original bacteria.