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目的观察大鼠急性内囊出血后血液流变特性的经时变化,总结变化规律,分析其对微循环的影响。方法将大鼠随机分为假手术组及出血组,后者又分为出血后3、6、12、24h四个亚组,每组6只。尾尖剪断取自体血0.1ml定位注射至大鼠右侧内囊,假手术组除不注血外,其余操作同出血组。假手术组即刻取血,出血组分别于各时间点取血做血液流变学检测。结果各出血组与假手术组比较,血液流变学各指标总体水平呈上升趋势(P<0.05);出血各组间比较,全血低切黏度在出血后3～12h明显升高,全血高切黏度、血浆黏度在24h升高最明显,红细胞压积(HCT)、红细胞聚集指数(EAI)及纤维蛋白原(Fib)含量随时间推移逐渐升高,前者在24h达高峰,后两者高峰时间为出血后12～24h。结论大鼠急性内囊出血后不同时段的血液流变学参数发生了有统计学意义的改变,将影响中枢神经系统的微循环功能。
Objective To observe the changes of hemorrheology after acute intracapsular hemorrhage in rats and to summarize the changes of hemorrheology and analyze the effects on the microcirculation. Methods The rats were randomly divided into sham operation group and hemorrhage group. The latter group was divided into four subgroups at 3, 6, 12 and 24 hours after hemorrhage, with 6 rats in each group. Tail tip cut from 0.1ml of body blood injection into the right side of the rat internal capsule, the sham group except without injection of blood, the rest of the operation with the bleeding group. Sham operation group immediately take blood, hemorrhage group were taken at each time point to do blood rheology test. Results Compared with the sham operation group, the overall level of hemorheology indexes showed an upward trend (P <0.05). Compared with the sham operation group, the whole blood low shear viscosity increased significantly 3 ~ 12 h after hemorrhage, High shear viscosity and plasma viscosity increased most significantly at 24h, and the content of hematocrit (HCT), erythrocyte aggregation index (EAI) and fibrinogen (Fib) increased gradually with the passage of time. The former peaked at 24h and the latter two Peak time after bleeding 12 ~ 24h. Conclusion There are statistically significant changes in hemorheology parameters at different time points after acute ICH in rats, which will affect the microcirculation function of central nervous system.