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近来,关于维生素D研究的重要进展之一就是1,25(OH)_2D_3的受体不仅存在于维生素D的经典靶器官内,如肠、骨和肾,而且还存在于所谓的“非经典”的靶器内,如垂体、胰腺、甲状旁腺、性腺和胎盘。Murdoch、Norman和 Merke认为1,25,(OH)_2D_3参与垂体、胰腺和性腺的激素合成与分泌。Ⅱ型维生素D依赖性佝偻病(DDR-Ⅱ)是一种新的激素不应症。表现为严重的佝偻病、全身无毛发,对抗1,25(OH)_2D_3。其主要原因是1,25(OH)_2D_3的受体有缺陷。这种病人为研究上述问题
Recently, one of the most important progresses in vitamin D research is that the receptors of 1,25 (OH) _2D_3 exist not only in the classical target organs of vitamin D such as intestine, bone and kidney, but also in the so-called “non-canonical” Such as the pituitary gland, pancreas, parathyroid gland, gonads and placenta. Murdoch, Norman and Merke that 1,25, (OH) _2D_3 involved in pituitary, pancreatic and gonadal hormone synthesis and secretion. Type II vitamin D-dependent rickets (DDR-II) is a new hormone refractory disease. The performance of a serious rickets, the whole body without hair, against 1,25 (OH) _2D_3. The main reason is that the receptor of 1,25 (OH) _2D_3 is defective. This patient is studying the above problem