目的:报道2例IVF治疗中卵子发育障碍原发性不孕姐妹患者。方法:对本院收治的2例卵子发育障碍原发性不孕患者姐妹进行回顾性总结与分析。结果:均采用常规GnRHa长方案促排卵,取卵日卵泡穿刺镜检仅见卵丘颗粒细胞团,均未见到卵子,补救性hCG治疗亦未取得卵子,诊断为卵子发育异常。追问病史得知其祖父母为表兄妹近亲婚配。患者(妹妹)行受卵治疗,宫内单胎成功妊娠。结论:门诊IVF治疗建病历时应详细询问患者家族史,供卵方案是目前IVF治疗卵子发育障碍原发性不孕较常用且有效的方法。 OBJECTIVE: To report two cases of primary infertility sisters with oophorosis in IVF treatment. Methods: Two sisters with primary infertility due to ooplasm dysplasia were retrospectively reviewed and analyzed in our hospital. Results: Ovulation was induced by the conventional GnRHa long protocol. Ovarian granulosa cells were observed only by follicular laparoscopy. None of the oocytes were found in the oviduct, and no ovum was detected by the rescue hCG treatment. Asked about the medical history of their grandparents know cousins ​​marriage. Patients (sister) line by egg treatment, intrauterine pregnancy single pregnancy. Conclusion: Outpatient IVF therapy should be asked about the history of patients should be asked in detail about the family history of patients, ovarian IVF treatment of primary infertility is more commonly used and effective method of developmental disorders.