药物动力学(PK)模型的选择在PK研究的理论和实践中具有重要意义。PK模型的选择已有多种方法和指标[1～3]。本文将信息论中的最大熵原理[4]试用于PK模型的选择。1　原理当随机变量ε服从正态分布时,根据最大熵定理[4],有Hmax=Log(2πeσ2)/2(1)式中,2,π,e均为常数,因此,Hmax值 The choice of pharmacokinetic (PK) model is of great importance in the theory and practice of PK research. There are many methods and indicators for the selection of PK model [1 ~ 3]. In this paper, the maximum entropy principle in information theory [4] is applied to the selection of PK model. 1 Principle When the random variable ε obeys the normal distribution, Hmax = Log (2πeσ2) / 2 (1), where 2, π and e are constants according to the maximum entropy theorem [4]