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过去的研究发现,在肾功能正常或受损时戊烷脒多次给药,血浆内药物积蓄会导致中毒,因此有必要了解戊烷脒单次及多次给药的血浆药动学。病人和方法研究对象分为3组:①组为急性卡氏肺囊虫性肺炎患者10例,其肾功能正常:②组为末期肾病接受血透治疗而并非卡氏肺囊虫性肺炎患者9例;③组为急性卡氏肺囊虫性肺炎患者5例,在戊烷脒治疗后其肾功能正常或轻度不正常者,作为门诊病例观察。静滴羟乙磺酸戊烷脒(pentamidine isothio-nate)3mg/kg,每日一次,两小时滴完。
Past studies have found that in patients with normal or impaired renal function pentamidine administration, plasma drug accumulation will lead to poisoning, it is necessary to understand pentamidine single and multiple plasma pharmacokinetics. Patients and methods The subjects were divided into three groups: ① group of acute cardiopulmonary Pneumocystis pneumonia in 10 patients with normal renal function: ② group for end-stage renal disease rather than hemodialysis cardiopulmonary Pneumocystis pneumonia patients 9 Cases; ③ group of acute cardiopulmonary Pneumocystis pneumonia in 5 patients, after pentamidine treatment of renal function was normal or mild abnormal, as outpatients observed. Intravenous pentamidine isothio-nate 3mg / kg, once daily, two hours dripping finished.