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目的观察分析吡格列酮对高血压合并糖耐量异常的疗效。方法收集高血压合并糖耐量异常患者100例,随机分成对照组和药物干预组,50例/组。两组患者均给予饮食、远动及降压药治疗,药物干预组另加盐酸吡格列酮治疗。随访18个月,观察两组患者Ⅱ型糖尿病、冠心病和脑血管疾病的发生情况及血压变化情况。结果药物干预组Ⅱ型糖尿病、冠心病和脑血管疾病的发生率均显著低于对照组(P<0.01),药物干预组患者血压显著低于对照组(P<0.01)。结论高血压合并糖耐量异常患者在常规治疗基础上加用吡格列酮可有效降低Ⅱ型糖尿病、冠心病和脑血管疾病的发生率,且有助于更好的控制血压。
Objective To observe the effect of pioglitazone on hypertension with impaired glucose tolerance. Methods 100 patients with hypertension and impaired glucose tolerance were collected and randomly divided into control group and drug intervention group, 50 cases / group. Two groups of patients were given diet, teleconnection and antihypertensive drugs, drug intervention group plus pioglitazone hydrochloride. The patients were followed up for 18 months. The incidence of type 2 diabetes mellitus, coronary heart disease and cerebrovascular disease and blood pressure were observed in two groups. Results The incidence of type 2 diabetes mellitus, coronary heart disease and cerebrovascular disease in the drug intervention group was significantly lower than that in the control group (P <0.01). The blood pressure of the drug intervention group was significantly lower than that of the control group (P <0.01). Conclusion Patients with hypertension and impaired glucose tolerance can effectively reduce the incidence of type 2 diabetes mellitus, coronary heart disease and cerebrovascular disease by adding pioglitazone on the basis of routine treatment, and help to control blood pressure better.